CRESCO HPC Infrastucture. All computing facilities in ENEA are integrated within ENEAGRID, an infrastructure for distributed computing over 6 sites whose main facilities are the HPC CRESCO clusters. CRESCO6 installed in ENEA Portici is a HPC system consisting of 434 nodes, ranked 420th in the TOP500 list of Nov. 2018, 1.4 PFlops. It is a Lenovo ThinkSystem SD530 platform, an ultra-dense two-socket server in a 0.5 U rack form factor inserted in a 2U four-mode enclosure. The infrastructure is deeply involved in application in alternative energies, energy efficiency, climate and environment, new materials, manufacturing technologies, bioinformatics, transports, security and cultural heritage.